Skip to main content Skip to main navigation menu Skip to site footer

Platelet-rich plasma improves initial bone remodeling


Objective: To compare the osteoblast cell formation process after installation implant with and without added of platelet-rich plasma (PRP). Methods: Twenty-four male rabbit were selected by purposive sampling, divide into two groups. Group 1 implant with added PRP were installation in the distal part of the thigh bone 12 male rabbits, Group 2 implants without the addition of PRP mounted on the distal part of the thigh bone 12 male rabbits. All rabbits in euthanasia after 0, 7, 14, and 28 days were then analyzed histologically to determine the formation of osteoblast cells. Results: There is increased formation of osteoblast cell formation in implant installation with the addition of PRP when compared with implants without PRP as time increases. Conclusion: Administration of PRP in implants can speed up and increase osteoblast cell formation.


  1. Camarini ET, Janoni JN, Leile PCC, et al. Use of biomaterial with or without platelet-rich plasma in post extraction sites, a microscopic study in dogs. Int J Oral Maxillofac Implants 2009;24: 432-438.
  2. Schmitz JP, Hollinger JO. The biology of platelet-rich plasma. J Oral Maxillofacial Surg 2001;59: 1119-1121.
  3. Al-Hezaimi K, Nevins M, Kim SW, et al. Efficacy of growth factor in promoting early Osseo integration. J Oral Implantol 2014;40: 543-548.
  4. Weibrich G, Hansen T, Kleis W, et al. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 2004;34: 671-665.
  5. Max RE, Carlson ER, Eichstaedt RM, et al. Platelet rich plasma: growth factor enhancement for bone grafts. Oral Surg. Oral Med Oral Pathol Oral Radiol Endod 1998;85: 638-646.
  6. Menezes DJ, Shibli JA, Gehrke SA, et al. Effect of platelet-rich plasma in alveolar distraction osteogenesis; a controlled clinical trial. Br J Oral Maxillofac Surg 2016;54: 83-87.
  7. Zechner W, Tangle S, Tepper G, et al. Influence of platelet-rich plasma on osseous healing of dental implant; a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants 2003;18: 15-22.
  8. Marx RE. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP. Implant Dent 2001;10: 225-228.
  9. Eberhardt C, Habermann B, Tiemann S, et al. Improvement of Osseo integration of cement less metal implant under bandronate is dose pendent bone. Bone 2006;39: 276-282.
  10. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet rich plasma. Growth factor enhancement for bone graft, oral surg oral med oral pathol oral radiol endod 1998;85: 638-646.
  11. Marx RE. Platelet-rich plasma: evidence to support its use. J Maxillofac Surg 2004;62: 489-496.
  12. Kanthan SR, Kavitha S, Addi S, et al. Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: A preliminary study involving rabbit models. Injury Int J 2011;1: 8-11.
  13. Garg A. The use of platelet rich plasma to enhance the success of bone grafts around dental implants. Dent Implantol 2000;11: 9-11.
  14. Schliephake H, Aref A, Scharnweber, et al. Effect of modifications of dual acid-etched implant surfaces on peri- implant bone formation. Part I: organic coatings. Clin Oral Implants Res 2009;20: 31-37.
  15. Wilt fang J, Schlegel K, Zimmermann R, et al. Evaluation of bony regeneration following sinus lift procedures with bone substitutes and platelet rich plasma. Ditch Zahnaerztl Z 2002;57: 38-42
  16. Gruber R, Varga F, Fischer MB, et al. Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, micro particles and membranes. Clin Oral Implants Res 2002;13: 529-535.
  17. Weibrich G, Gnoth SH, Otto M, et al. Stimulation of the proliferation rate of human osteoblast like cells by platelet concentrates in vitro. Mund-Kiefer-Gesichtschir 2002;6: 168-174.
  18. Pollard JW. Tumour – stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis. Breast Cancer Res 2001;3: 230-237.
  19. Terheyden H, Roldan-Ossa JC, Miller J, et al. Platelet-rich plasma in bone regeneration. Preliminary results of two experimental studies. Implantog 2002;10: 195-205.
  20. Kiuru J, Viinikka L, Myllyla G, et al. Cytoskeleton-dependent release of human platelet epidermal growth factor. Life Sci 1991;49: 1997-2003.
  21. Wariz R, Ou KL, Ruslin M, et al. Long exposure of argon plasma coagulation induce more thermal damage accompanied by a higher expression of NF-?B and caspase-3. J Dentomaxillofac Sci 2018;3: 62-69.

How to Cite

Machmud, E., Thalib, B., Dharmautama, M., Mude, A. H., Dammar, I., & Ikbal, M. (2020). Platelet-rich plasma improves initial bone remodeling. Journal of Dentomaxillofacial Science, 5(3), 158–161.




Most read articles by the same author(s)

> >>