Cardiovascular and periodontal diseases are common inflammatory conditions in the human population. Tlymphocytes
participate
in
the

pathogenesis and inflammatory events of atherosclerosis. These immune cells enter the
inflamed artery wall and join macrophages via a number of interferon-c-inducible chemokines. Chemokines (IL-8),
cytokines, and growth factors also participate in this process. The interaction between interleukin- 8 and its receptor,
CXCR2, can also contribute to lesion formation in mice. The main causes of aggressive periodontitis is
Actinobacillus
actinomycetemcomitans
. Previous studies have proven that adhesin protein with 24 kDa molecular weight from
A.actinomycetemcomitans is a specific adhesin, this adhesin proteins play a role in the adhesion process on host. this
kind adhesion in the epithelial attachment would lead to colonization and invasion of
A.actinomycetemcomitans that
will stimulate the host immune response. This study aimed to analyze the influence of induction 24 kDa
A.actinomycetemcomitans adhesin protein to the titre of IL-8 in heart of Wistar rat with aggressive periodontitis using
Elisa method to measure and analyze the titre of IL-8. After analyzed with analysis of variance, showed significant
differences of IL-8 titre in the control group and the group with the induction by
A.actinomycetemcomitans,
A.actinomycetemcomitans plus 24 kDa A.actinomycetemcomitans adhesin protein, and only with 24 kDa
A.actinomycetemcomitans adhesin protein. It can be concluded that A.actinomycetemcomitans adhesin protein with 24
kDa molecular weight has a role in increasing of IL-8 titre in heart wistar rat with aggressive periodontitis.

The sap of ambonese banana (Musa paradisiaca var sapientum) contain flavonoids, saponins, tannins which have been
widely used by people in Trunyan Bali as traditional medicine on wound healing, and it has been reported as a
potential wound healing after tooth extraction. The aim of this research was to determine the level of safety of using
herbal medicine, ambonese banana stem extract on histopatology liver of mice with LD
parameters. This experimental
study was performed by
the post test only controlled group design. The sample were 28 mice (Mus musculus) randomly
divided into 4 groups. K group as control group was given aquadest. P1, P2, and P3, as treatment groups were given
ambonese banana stem extract with dose 0.42g/20gbw, 2.1g/20gbw, 4.2g/20gbw. The extract was given per-oral with
sonde on the first day. On day 3, the mice were terminated, and the livers were microscopically histopathological
observed. The observed at 3
th
50
day, there were no deaths in every groups of mice (K, P1, P2, and P3) on the third day
observation. Kruskal Wallis test showed there was not significant difference in histopathological appearance on liver
of mice (p=0.771)
. It wasconcluded that the maximumsafety dose that can still be administered is 0.42g/20gbw following
the LD
parameter. Theacute toxicity test of ambonese banana stem extract did not show necrosis on liver but it showed
the highest simple degeneration than all groups which were given 0.42g/20gbw dose.

At the beginning of the growth, tooth inclination is mesioangular, then move gradually to come into contact with the
distal surface of the second molar and further commit to sliding movement parallel to second molar axis. This position
will be retained to achieve the eruption way to oral cavity. However, the last decade reported incidence increased
impaction of the third molar teeth in the lower jaw. This study was aimed to study the level of pre-eruption of mandibular
third molar in the population group aged 14-17 years to predict the risk of tooth impaction or not. Differentiated
populations on cluster I, age 14-15 years old; group II, 15.1-16 years old; and group III 16.1-17 years old. Research
carried out by clinical observation and measurement of at Department of Radiology in Jember University with 48
people selected based on predetermined criteria. X-ray projection was exposed by paralleling technique on the lower
third molar teeth, left and right. The results showed 43.75% of 14-15 year old group had the third molar angle interval
50-56°; 15.1-16 year age group, 80% have 57-70° angle interval, and 16.1-17 years age group, 46.67% has angular
interval 64-70°. It was concluded that a large interval of the third molar angle increase due to the increased of age,
and the angle is different between groups based on gender.

Caries in infant was influenced by their substrat. Substrats are the primary source of energy in bacterial colonising
process in oral cavity. Streptococcus mutans are especially the main cause of tooth decay. For 1-year-old infant the
primary nutritions are generally from breast milk or formula milk. This study was aimed to determine the different
numbers of bacterial colonizations of S.mutan found in breast-fed infants from those found in formula milk. This
observational-analytics study used cross sectional study design was carried out to 60 infants who fulfil the inclution
criteria of simple random sampling method,30 infants in each group from Integrated Health Centre in Kelurahan Antang
,
and the bactery on the saliva was evaluated in Microbiology Laboratory of Medical Faculty Hasanuddin University. Each
parent was given questionnaire which to asks the things related with this research and microbial screening was taken
from saliva of 1-year old infant. The number of bacterial colonizations for S.mutans in breastfeeding group shows mean
value 19.7 CFU/ml while the formula milk group was about 37.97 CFU/ml, so the consumptions of breast milk and
formula milk in 1-year old infant show the significantly different number of bacterial colonizations of S.mutans in. It
was concluded that colonization of S.mutans in breastfeeding group lower than formula milk group.

Grinding or clenching teeth during sleep or unconsciously called bruxism. Bruxism is a bad habit that is occured in
almost people, from children to adults. Bruxism closely related to changes in tooth morphology due to erosion of tooth
surfaces
, especially on the occlusal area. This study aimed to determine the morphological changes of permanent teeth
due to bruxism. By using the method of observational analytic and cross-sectional design, the sample set in adults who
experience bruxismas many as 69 samples; 23 samples do bruxismand 46 samples do not do bruxism. The results showed
that the morphological changes on occlusal and incisal surfaces of the teeth in 78.3% of samples undergo bruxism, and
samples do not undergo morphological changes as much as 21.7%. 6.5% of samples who did bruxism had dental
morphology changes, and the prevalence is higher in men than women. With the chi-square test, it is known that there
is significant effect (p<0.05) of bruxism on morphological changes of permanent teeth. It was concluded that bruxism
affect the morphological changes of permanent teeth.

Allergic stomatitis or stomatitis venenata is a hypersensitivity reaction caused by an allergen from medicines, foods,
dental materials (restoration material, prosthetic, orthodontic appliance, mercury, acrylic, cobalt). This report will
discusses the management of food allergic stomatitis. The common cause of food allergy in adult patients are orange
(citrus fruit), nuts, fish, marine fish and wheat. Oral manifestations of allergic stomatitis begin with multiple vesicles
and becomes fibrin-covered ulcers with erythematous edges accompanied by inflammation and pain. The patient was a
53-year-old woman who has suffered stomatitis since 6 months ago, and had seen dentist in private practice and
government dental-practice (hospitals and health centers). The patient has an a allergy history. Intra oral examination
found the presence of multiple ulcers on the buccal mucosa upper right, cheek mucosa lower right and tongue. The
final diagnosis of the case is allergic stomatitis due to daily food alergic base on anamesis, clinical examination and
laboratory tests. Treatment to prevent allergic stomatitis causes, symptomatic therapy, and topical corticosteroids. It
was concluded that management of allergic stomatitis should avoid the food as primary causes, giving mouthwash
containing analgesic/anti-inflammatory and topical corticosteroids.